NERIC 2017 Speakers

Jason McLellan, PhD

Jason McLellan, PhD

Assistant Professor of Biochemistry, Geisel School of Medicine at Dartmouth

Jason McLellan earned a BS in chemistry with an emphasis in biochemistry from Wayne State University in Detroit, Michigan. He later earned a PhD in biophysics from the Johns Hopkins School of Medicine in Baltimore, Maryland while working in the laboratory of Prof. Dan Leahy where he investigated molecular mechanisms involved in the Hedgehog signal transduction pathway. He then carried out postdoctoral research at the National Institutes of Health’s Vaccine Research Center working in the laboratory of Dr. Peter Kwong to investigate the structural basis of antibody-mediated neutralization of HIV-1. During this time, he began collaborating with Dr. Barney Graham to apply principles of structure-based vaccine design to respiratory syncytial virus (RSV). In 2013, Jason joined the faculty at the Geisel School of Medicine at Dartmouth as an Assistant Professor of Biochemistry. His research seeks to translate structural and mechanistic information on host-pathogen interactions into preventive and therapeutic treatments for infectious human diseases. Pneumoviruses and coronaviruses are currently the two major pathogens being investigated in his lab. These research programs are highly collaborative and include domestic and international researchers from academia, government, and industry.

Selected Publications
Rossey I, Gilman MS, Kabeche SC, Sedeyn K, Wrapp D, Kanekiyo M, Chen M, Mas V, Spitaels J, Melero JA, Graham BS, Schepens B, McLellan JS, Saelens X. Potent single-domain antibodies that arrest respiratory syncytial virus fusion protein in its prefusion state. Nat Commun. 2017 Feb 13;8:14158. PMID: 28194013

Gilman MS, Castellanos CA, Chen M, Ngwuta JO, Goodwin E, Moin SM, Mas V, Melero JA, Wright PF, Graham BS, McLellan JS, Walker LM. Rapid profiling of RSV antibody repertoires from the memory B cells of naturally infected adult donors. Sci Immunol. 2016 Dec 16;1(6). pii: eaaj1879. PMID: 28111638

Más V, Rodriguez L, Olmedillas E, Cano O, Palomo C, Terron MC, Luque D, Melero JA, McLellan JS.  Engineering, Structure and Immunogenicity of the Human Metapneumovirus F Protein in the Postfusion Conformation. PLoS Pathog. 2016 Sep 9;12(9):e1005859. PMID: 27611367

Misasi J, Gilman MS, Kanekiyo M, Gui M, Cagigi A, Mulangu S, Corti D, Ledgerwood JE, Lanzavecchia A, Cunningham J, Muyembe-Tamfun JJ, Baxa U, Graham BS, Xiang Y, Sullivan NJ, McLellan JS. Structural and molecular basis for Ebola virus neutralization by protective human antibodies. Science. 2016 Mar 18;351(6279):1343-6. PMID: 26917592

Kirchdoerfer RN, Cottrell CA, Wang N, Pallesen J, Yassine HM, Turner HL, Corbett KS, Graham BS, McLellan JS, Ward AB. Pre-fusion structure of a human coronavirus spike protein. Nature. 2016 Mar 3;531(7592):118-21. PMID: 26935699

Battles MB, Langedijk JP, Furmanova-Hollenstein P, Chaiwatpongsakorn S, Costello HM, Kwanten L, Vranckx L, Vink P, Jaensch S, Jonckers TH, Koul A, Arnoult E, Peeples ME, Roymans D, McLellan JS.  Molecular mechanism of respiratory syncytial virus fusion inhibitors. Nat Chem Biol. 2016 Feb;12(2):87-93.  PMID: 26641933

Agenda

(Information subject to change)

Wednesday, August 16th

2:00 - 9:00 PM Registration Desk Hours of Operation (Diamond Foyer)
5:00 - 6:00 PM Reception and Poster Session I Setup (Emerald Promenade)
6:00 - 6:15 PM Welcoming Remarks (Emerald I-III Ballrooms) Ralph Budd, MD, Director, Vermont Center for Immunology and Infectious Diseases, UVM College of Medicine, Judith Van Houten, PhD,  Director, Vermont Genetics Network, UVM President Thomas Sullivan and UVM Provost David Rosowsky, PhD
6:15 - 7:30 PM Plated Dinner (Emerald I-III Ballrooms)
7:30 - 9:00 PM Poster Session I (Undergraduate students and Cores) (Emerald Promenade)

Thursday, August 17th

COBRE/INBRE Business Grant Managers Meeting with Arina Kramer, Grants Specialist at the Center for Research Capacity Building, NIGMS (Carlton Boardroom)
7:00 AM - 5:30 PM Registration Desk Hours of Operation (Diamond Foyer)
7:00 - 8:15 AM Breakfast, Career Tables for interested students, Poster Session II Set-up (Exhibition Hall)
8:30 - 9:15 AM Opening Remarks (Emerald I-III Ballrooms) NIGMS staff:
9:30 - 10:00 AM Break and Refreshments (Emerald Promenade)
10:00 - 12:00 PM Concurrent Sessions
  1. Core Presentations of resources available to NERIC investigators (about 20 min each, followed by table discussions with individual Core leaders) (Emerald III Ballroom)
    • Eric Kmiec, PhD, Helen F. Graham Cancer Center & Research Institute, Newark, DE
      "CRISPR-based Gene Editing in Biomedical Research"
    • Youngwook Ahn, PhD, Brown University Transgenics and Gene-Targeting Facility
      “CRISPR/Cas9 Mouse Preparation”
    • Bongsup Cho, PhD, Coordinator INBRE and Professor, The University of Rhode Island
      "Expanding Bioinformatic Core: 3D printing of molecules and viruses!”
    • Nagib Ahsan, PhD, Brown University
      "Proteomics Core Facility"
    • Calvin Vary, PhD, Maine Medical Research Institute
      "Lipidomics"
    • Dwight Matthews, PhD, University of Vermont
      "Metabolomics and 13C-labeling"
  2. Entrepreneurship Workshop: how to turn your innovative ideas into reality. (Emerald II Ballroom)
    • Keynote speaker, Mathew Portnoy, PhD, Overall HHS SBIR/STTR Program Manager, NIH Program Manager, NIH Office of Extramural Programs
    • Pitch presentations by IDeA entrepreneurs
    • Mercedes Rincón, PhD,  Associate Professor, Medicine Immunobiology Program, UVM College of Medicine
      "Welcome to the I-Trep program for IDeA states"
    • Three Round tables, topics to choose
  3. INBRE Program (Emerald I Ballroom)
    • 10:00 - 11:00 AM - Sharon O'Connor, MS, MBA, Internal Evaluation Manager, Dartmouth College, New Hampshire INBRE
      "INBRE Program Evaluation"
    • 11:00 - 12:00 PM - Elizabeth Ambos, PhD, Executive Officer, Council on Undergraduate Research
      "PM Council on Undergraduate Research Presentation"
10:30 - 11:30 AM COBRE/INBRE Business Grant Managers Meeting with Arina Kramer, Grants Specialist at the Center for Research Capacity Building, NIGMS (Carlton Boardroom)
12:00 - 1:30 PM Lunch and Networking (Exhibition Hall)

VGN Baccalaureate Partner Institution Meeting (Carlton Boardroom)
1:30 - 3:30 PM Concurrent Scientific Sessions (solicit themes from PIs and from abstracts received). Development/Genetics (Emerald I Ballroom) Chair, Cancer (Emerald III Ballroom) Chair,
  • Featured Speaker: Patrycja Dubielecka, PhD, Brown University
    “Beyond JAK/STAT: Signaling Pathways Contributing to the Pathogenesis of Myeloproliferative Neoplasms”
Infectious Diseases and Immunology (Emerald II Ballroom) Chair, William Green, PhD, Professor of Microbiology and Immunology, Geisel School of Medicine, Dartmouth
3:30 - 3:45 PM Break and Refreshments (Emerald Promenade)
3:45 - 4:45 PM Keynote Lecture I (Emerald III Ballroom)
4:45 - 6:00 PM Poster Session II (Graduate students and Postdoctoral Fellows) (Emerald III Ballroom)
6:00 PM Dinner on your own in Burlington

Friday, August 18th

8:00 - 9:00 AM Breakfast (Exhibition Hall)
9:00 - 10:00 AM Cool ideas from IDeA programs (Emerald III Ballroom)
  • Bruce Stanton, PhD, Professor of Microbiology and Immunology, Geisel School of Medicine, Dartmouth
    “Leveraging COBRE Resources with Philanthropy”
  • Marie Stuart, MD, PI of SCD COBRE Program, Director of Hematology Research A.I. DuPont Hospital for Children
    “Single Disease Centered COBREs…A Novel Approach”
  • W. Kelley Thomas, PhD, Professor, Dept. Molecular, Cellular and Biomedical Sciences, University of New Hampshire
    “Early Undergraduate Experiences in Bioinformatics”
10:00 - 12:00 PM Concurrent Scientific Sessions Neuroscience (Emerald I Ballroom) Chair, Judith Van Houten, PhD
  • Featured Speaker: Matthew E. R. Butchbach, PhD, University of Delaware
    "Characterization of Small Molecule Neuroprotectants for Spinal Muscular Atrophy”

Cardiovascular and Pulmonary Systems (Emerald III Ballroom) Chair, Bruce Stanton, PhD

Bioinformatics, Computational Biology, Complex Systems (Emerald II Ballroom) Chair, Cathy Wu, PhD, Edward G. Jefferson Chair of Bioinformatics & Computational Biology, University of Delaware
  • Featured Speaker: Benjamin King, PhD, University of Maine
  • Featured Speakers: Dr. Malcolm D’Souza and Dr. Derald Wentzien from Delaware INBRE Wesley College
    “Undergraduate Data Science Research Projects Form an Integral Component of the Wesley College Science and Mathematics Curriculum”
12:00 - 1:00 PM Lunch and Networking Box lunches (G's Restaurant)
1:00 PM Conference Concludes