NERIC 2017 Speakers

Eric Kmiec, PhD

Eric Kmiec, PhD

Director, Gene Editing Institute
Helen F. Graham Cancer & Research Institute
Christiana Care Health System

B.A. Rutgers University
M.S. Southern Illinois University
Ph.D. University of Florida School of Medicine

Eric B. Kmiec, Ph.D., is well-known for his pioneering work in the fields of molecular medicine and gene editing. Throughout his professional career, Dr. Kmiec has led research teams in developing gene editing technologies and genetic therapies for inherited disorders such as Sickle Cell Disease. He is the recipient of multiple research awards from the National Institutes of Health (RO1s, R21s), the American Cancer Society, and private foundations including the 2012 Proudford Foundation Unsung Hero Award in Sickle Cell Disease. He has been a member of numerous editorial boards, NIH study sections and review boards and is the (primary/senior) author of more than 145 scientific publications (mostly in genetic recombination and gene editing).

He holds 18 issued patents, most of which have been licensed by biotechnology and pharmaceutical companies and has founded two biotechnology companies. He is a senior scientific advisor and SAB member of ETAGEN, a gene editing company located in Cambridge, Massachusetts, centered on the development of therapeutic uses of gene editing. Dr. Kmiec has been the primary mentor for 18 Ph.D. students and 4 MS students, all of whom have attained scientific positons. He has held or holds major administrative posts in various on NIH regional and state biomedical research grants, including IDeA Network of Biomedical Research (INBRE) and Centers of Biomedical Research Excellence (COBRE). Dr. Kmiec was also honored as the Eminent Scholar in residence at Marshall University (Huntington, West Virginia) in 2009-2011 and was elected as an Honorary Commander of the 436th Air Wing at Dover Air Force Base in Dover, Delaware for in 2013 and again in 2014.

The Gene Editing Institute, founded by Dr. Kmiec, is a core facility providing genetic tools for gene editing as well as instruction in the design and implementation of these tools for collaborators and colleagues nationwide. Currently, the Institute is working with a variety of groups within the Delaware/ IDeA state network and has recently developed an educational module for instruction of gene editing in undergraduate teaching laboratories. This module will be licensed, marketed and sold through an international biotechnology company.

Agenda

Wednesday, August 16th

2:00 - 9:00 PM Registration Desk Hours of Operation
(Diamond Foyer)
5:00 - 6:00 PM Reception and Poster Session I Setup
(Promenade)
6:00 - 6:15 PM Welcoming Remarks
(Emerald I-III Ballrooms)

6:15 - 7:30 PM Plated Dinner
(Emerald I-III Ballrooms)
7:30 - 9:00 PM Poster Session I (Undergraduate students and Cores)
(Promenade)

Thursday, August 17th

7:00 AM - 5:30 PM Registration Desk Hours of Operation
(Diamond Foyer)
7:00 - 8:15 AM Breakfast, Career Tables for interested students (Exhibition Hall), Poster Session II Set-up
(Promenade)

  • Tim Hunter, MS, Biotek and Yolanda Nesbeth PhD, Celdara Medical
    "Biotech Career"
  • Corine Farewell, DVM, MBA UVM Innovations
    "Technology Transfer"
  • Charles Irvin, PhD, UVM College of Medicine, Director, Vermont Lung Center, and Ralph Budd, MD, UVM College of Medicine, Director, Vermont Center for Immunology & Infectious Diseases
    "Academic Career"
  • Yanping Liu, MD, PhD, NIH, NIGMS
    "Scientific Careers in Government"
  • Daniel Kolker, PhD, United States Patent and Trademark Office
    “Patent Assessment”
  • Karen Spach, PhD, Senior Medical Writer, Envision Pharma Group
    "Scientific Careers in Government"
8:30 - 9:45 AM Opening Remarks
(Emerald I-III Ballrooms)

NIGMS staff:

  • Yanping Liu, MD, PhD Program Director, NIGMS
    “Overview of Programs in the Center for Research Capacity Building”
  • Arina Kramer, Grants Specialist at the Center for Research Capacity Building, NIGMS
    “IDeA Post Award Management”
9:45 - 10:00 AM Break and Refreshments
(Promenade)
10:00 - 12:00 PM

Concurrent Sessions

  1. Core Presentations of Resources Available to NERIC Investigators
    (Emerald III Ballroom) Chair, Ralph Budd, MD, University Distinguished Professor of Medicine, The University of Vermont Larner College of Medicine

    • Eric Kmiec, PhD, Helen F. Graham Cancer Center & Research Institute, Newark, DE
      "CRISPR-based Gene Editing in Biomedical Research"
    • Youngwook Ahn, PhD, Brown University Transgenics and Gene-Targeting Facility
      “CRISPR/Cas9 Mouse Preparation”
    • Bongsup Cho, PhD, Coordinator INBRE and Professor, The University of Rhode Island
      "Expanding Bioinformatic Core: 3D Printing of Molecules and Viruses!”
    • Nagib Ahsan, PhD, Brown University
      "Proteomics Core Facility"
    • Calvin Vary, PhD, Maine Medical Research Institute
      "Lipidomics"
    • Dwight Matthews, PhD, University of Vermont
      "Metabolomics and 13C-labeling"
  2. Entrepreneurship Workshop: "How to Turn Your Innovative Ideas Into Reality"
    (Emerald II Ballroom)

    • Mercedes Rincón, PhD,   University of Vermont
      "Welcome to the I-Trep program for IDeA states"
    • Keynote speaker, Mathew Portnoy, PhD, Overall HHS SBIR/STTR Program Manager, NIH Program Manager, NIH Office of Extramural Programs
    • Pitch presentations
      • Voot Yin, PhD, MDI Biological Laboratory
      • Qian Chen, PhD, The Warren Alpert Medical School of Brown University/Rhode Island Hospital
    • Round tables (20 minutes each, choose three)
      • Daniel Kolker, PhD, Supervisory Patent Officer, USPTO, and MaryDilys Anderson, PhD, Esq, Finch & Maloney PLLC)
        “Assessing your Invention and Intellectual Property”
      • Samantha Roach-Gerber, VCET, and Erik Monsen, PhD, University of Vermont
        “How To Pitch-How to Sell Your Idea”
      • Cairn Cross, Fresh Tracks Venture
        “Funding Through VC, Angels”
      • Mathew Portnoy, PhD, NIH SBIR Program, and Yolanda Nesbeth, PhD, Celdara Medical
        “Funding Through SBIR/STTR”
      • Sarah O'Connell Kalil, COO, Boston Microfluidics, and Tanya Kanigan, PhD, COO, Genomic Expression Inc.
        “Setting Up Your Startup”
      • Tina Thornton, PhD, University of Vermont
        “I-Trep Program Opportunities”
  3. INBRE Program (Emerald I Ballroom)
    • 10:00 - 11:00 AM - Sharon O'Connor, MS, MBA, Internal Evaluation Manager, Dartmouth College, New Hampshire INBRE
      "INBRE Program Evaluation"
    • 11:00 - 12:00 PM - Elizabeth Ambos, PhD, Executive Officer, Council on Undergraduate Research
      "PM Council on Undergraduate Research Presentation"
10:30 - 11:30 AM COBRE/INBRE Business Grant Managers Meeting with Arina Kramer, Grants Specialist at the Center for Research Capacity Building, NIGMS (Carlton Boardroom)
12:00 - 1:30 PM U.S. Senator Patrick Leahy (Exhibition Hall)

Lunch and Networking
(Exhibition Hall)
VGN Baccalaureate Partner Institution Meeting
(Carlton Boardroom)
1:30 - 3:30 PM

Concurrent Scientific Sessions
Development/Genetics (Emerald I Ballroom) Chair, Bruce Stanton, PhD, Professor of Microbiology and Immunology, Geisel School of Medicine, Dartmouth

  • Featured Speaker: Vicki Losick, PhD, MDI Biological Laboratory
    “Wound Healing the Fruit Fly Way”
  • Featured Speaker: Jodi Camberg, PhD, University of Rhode Island
    "Remodeling protein architectures leads to big changes in cell physiology"
  • Santina Snow, MDI Biological Laboratory
    “The Role of Specific Tissues in Coordinating Changes in Organismal Growth, Longevity and Resilience to Stress in Response to Reduced mRNA Translation in C. Elegans”
  • Aaron Brown, PhD, Maine Medical Center Research Institute
    “A Novel Human Pluripotent Stem Cell-Derived Model of Beige Adipogenesis for Development of Anti-Obesity Therapies”
  • Larissa Williams, PhD, Bates College
    “The Transcription Factor, Nuclear Factor, Erythroid 2 (Nfe2), is a Regulator of the Oxidative Stress Response During Danio Rerio Development”
  • Michaela Reagan, PhD, Tufts University
    “3D Tissue Engineered Design of Bone Marrow Adipose Tissue to Investigate the Influence of Myeloma on Adipocytes and Adipogenesis

Cancer (Emerald III Ballroom) Chair, Mercedes Rincon, PhD, Professor of Medicine, The University of Vermont Larner College of Medicine

  • Featured Speaker: Patrycja Dubielecka, PhD, Brown University
    “Beyond JAK/STAT: Signaling Pathways Contributing to the Pathogenesis of Myeloproliferative Neoplasms”
  • Sonali Barwe, PhD, Alfred I. DuPont Hospital for Children
    “Disseminated Patient-Derived Xenograft Models for Preclinical Testing of New Drugs for Pediatric Leukemia”
  • Mark Perfetto, University of Delaware
    “ADAM9 Cleaves EphrinB1 to Regulate Canonical Wnt Signaling and Colorectal Cancer Cell Migration”
  • Con Sullivan, PhD, University of Maine
    "A Role for the Tumor Necrosis Factor-Alpha-Induced Protein 8-like 1 Gene in Cancer and Inflammation"
  • Sigrid Langhans, PhD, Nemours/Alfred I DuPont Hospital for Children
    “Beta-Hairpin Peptide Hydrogels as Scaffolds for 3D High-Throughput Screening in Drug Discovery”
  • Andrea Villanti, PhD, MPH, Associate Professor, Vermont Center on Behavior and Health, Department of Psychiatry, University of Vermont
    “Characteristics of Young Adult Cigarette Smokers in the U.S.: Findings from the 1st Wave of the PATH Study, 2013-2014”

Infectious Diseases and Immunology (Emerald II Ballroom) Chair, William Green, PhD, Professor of Microbiology and Immunology, Geisel School of Medicine, Dartmouth

  • Featured Speaker: William Landesman, PhD, Green Mountain College
    “Drivers of Variation in theIxodes Scapularis Microbiome”
  • Jason Shapiro, MD, Alpert Medical School, Brown University
    “Immunoglobulin-A Coated Bacteria Represent a Unique Subset of the Microbiome in Patients with Inflammatory Bowel Disease”
  • Md Mahmudul Hasan, University of Vermont
    “Motility of E. Histolytica Through Host Extracellular Matrix: Involvement of Invadosome-like Actin Structures”
  • Rajiv Jumani, University of Vermont
    “Identification and Pharmacokinetic-Pharmacodynamic Modeling of a Piperazine-Based Drug Lead for Cryptosporidiosis”
  • Hacene Boukari, PhD, Delaware State University
    “Tracking HIV Viruses in Human Cervical Mucus”
  • Victoria DeVault, University of Vermont
    “Natural Genetic Variation within a 0.1Mbp Genetic Interval on Chromosome 1 Regulates NKT Cell Development and Function”
3:30 - 3:45 PM Break and Refreshments
(Promenade)
3:45 - 4:45 PM Keynote Lecture I
(Emerald III Ballroom)

  • Jason McLellan, PhD, Geisel School of Medicine at Dartmouth
    “Developing New Therapeutic Interventions to RSV Infection by Inhibiting the Metamorphosis of the RSV Fusion Glycoprotein”
4:45 - 6:00 PM Poster Session II (Graduate students and Postdoctoral Fellows)
(Promenade)
5:30 - 6:30 PM NIH COBRE and INBRE PI Meeting
(Universal Amphitheater)
6:00 PM Dinner on your own in Burlington

Friday, August 18th

8:00 - 9:00 AM Breakfast
(Exhibition Hall)
9:00 - 10:00 AM

Cool ideas from IDeA programs (Emerald III Ballroom) Chair, Charles Irvin, PhD, Professor of Medicine, The University of Vermont Larner College of Medicine

  • Bruce Stanton, PhD, Professor of Microbiology and Immunology, Geisel School of Medicine, Dartmouth
    “Leveraging COBRE Resources with Philanthropy”
  • Marie Stuart, MD, PI of SCD COBRE Program, Director of Hematology Research A.I. DuPont Hospital for Children
    “Single Disease Centered COBREs…A Novel Approach”
  • W. Kelley Thomas, PhD, Professor, Dept. Molecular, Cellular and Biomedical Sciences, University of New Hampshire
    “Early Undergraduate Experiences in Bioinformatics”
10:00 - 12:00 PM

Concurrent Scientific Sessions

Neuroscience (Emerald I Ballroom) Chair, Melissa A. Harrington, PhD, Associate VP for Research, Delaware State University

  • Matthew E. R. Butchbach, PhD, Nemours/Alfred I. duPont Hospital for Children
    "Characterization of Small Molecule Neuroprotectants for Spinal Muscular Atrophy”
  • Featured Speaker: Andrew Kennedy, PhD, Bates College
    "Targeting the Tet Enzymes to Enhance Cognition"
  • Neal Mecum, University of New England
    “Lacrimal Gland Excision in Male and Female C57BL/6 Mice Causes Pain- and Anxiety-like Behavior”
  • Michael Dash, PhD, Middlebury College
    “Synaptic Depotentiation Reduces Sleep Need”
  • Leslie Johnson, PhD, Johnson State College
    “More than Just ‘Baby Weight’: Perceived Postpartum Weight Bias and Well-Being in First-Time Mothers”


Infectious Diseases and Immunology II (Emerald III Ballroom) Chair, Ralph Budd, MD, University Distinguished Professor, Medicine, University of Vermont Larner College of Medicine

  • Michael Secinaro, University of Vermont
    “Glycolysis Primes Effector T Cells for Death Through the Induction of Caspase-3 Activity”
  • Melissa Maginnis, PhD, University of Maine
    “Characterization of Cellular Factors Required for JC Polyomavirus Invasion of Host Cells”
  • Abbas Raza, University of Vermont
    “Sex-Specific Regulation of CNS Autoimmunity by the Signal Lymphocytic Activation Molecule (Slam) Locus”
  • Danielle Dube, PhD, Bowdoin College
    “Discovery of Genes Required for Glycoprotein Biosynthesis in the Gastric Pathogen Helicobacter Pylori”
  • Scott Rusin, Dartmouth College
    “Identification of Candidate CK2 Substrates in Mitosis by Quantitative Phosphoproteomics”

Bioinformatics, Computational Biology, Complex Systems (Emerald II Ballroom) Chair, Cathy Wu, PhD, Edward G. Jefferson Chair of Bioinformatics & Computational Biology, University of Delaware

  • Featured Speaker: Benjamin King, PhD, University of Maine

    "microRNA co-expression network dynamics of Pseudomonas aeruginosa infection in the zebrafish, Danio rerio"
  • Featured Speakers: Dr. Malcolm D’Souza and Dr. Derald Wentzien from Delaware INBRE Wesley College
    “Undergraduate Data Science Research Projects Form an Integral Component of the Wesley College Science and Mathematics Curriculum”
  • Shawn Polson, PhD, University of Delaware
    “Markers to Metagenomes and Back Again: Bioinformatics advances toward understanding microbial viruses”
  • Edward Lyman, PhD, University of Delaware
    “Computational Approaches to GPCR Drug Discovery: The Membrane as a Therapeutic Target”
  • Cathy Wu, PhD, University of Delaware
    “Big Data to Knowledge: Integrative Literature Mining and Panomics Analysis for Kinase Cancer Drug Analytics”
12:00 - 1:00 PM Lunch and Networking
Box lunches
(G's Restaurant)
1:00 PM Conference Concludes