NERIC 2017 Speakers

Dr. Malcolm D’Souza

Dr. Malcolm D’Souza

Professor of Chemistry and
Associate Dean of Interdisciplinary/Collaborative
Sponsored Research
Professional Activities

In addition to my research in physical organic chemistry, I have projects, presentations, and publications in the areas of chemometrics, STEM education, obesity studies, and in the design of commercial databases that assist in the development of new pharmaceutical and agricultural products. 95 Wesley College undergraduates from my laboratory have earned national and regional recognitions, and 65 undergraduates are co-authors on 57 peer-reviewed publications.

I am the Principal Investigator on the Wesley College NIH-NIGMS (IDeA) INBRE, NSF-EPSCoR, NSF ARRA, Cannon Scholar (NSF S-STEM), and DEDO programs. In 2009, to mark the occasion of its 50th anniversary, the College of Liberal Arts and Sciences, Northern Illinois University, recognized me for my accomplishments as one of its 50 most distinguished alumni. In 2012, I was awarded the American Chemical Society’s E. Emmett Reid Award, which recognizes high-quality teaching in chemistry at small colleges in the Mid-Atlantic region. In 2016 I earned two mentoring awards; the NIH-NIGMS INBRE Sidney A. McNairy, Jr. Mentoring Award, and the Delaware BioScience Association, Educator of the Year-Higher Education Award.

Our continued success in the Wesley-mentored undergraduate research program in chemistry has been recognized with articles in the state’s flagship newspapers: The Delaware News Journal and The Delaware State News. Articles have also appeared in the Dover Post, Hockessin Community News, Milford Beacon, and Delaware Today.

In 2010, the Strategic Pharmaceutical Advisors (SRxA’s) Word on Health used our drug development informatics findings (http://srxawordonhealth.com/2010/07/26/fda-criticized-by-the-government-accountability-office/) to corroborate the criticism of the Food and Drug Administration (FDA) from the Government Accountability Office (GAO).

In October 2012, the European International Innovations, a magazine devoted to disseminating science, research, and technology information, featured the decade-long transformation that the Wesley undergraduate research program has produced. The article outlined how the program has created a dynamic and exciting environment where research drives undergraduate teaching for student benefit (http://wesley.edu/wp-content/uploads/2015/07/p86-88_Malcom_DSouza.pdf).

In June 2013, the well-read NerdWallet blog used our mentored research program as an example when putting forward compelling suggestions as to how to achieve success in diversifying the STEM fields (https://www.nerdwallet.com/blog/loans/student-loans/diversity-in-stem-fields/).

The initiatives for integrating project-based STEM learning into the College-core were featured in the May 2014 issue of International Innovations (http://wesley.edu/wp-content/uploads/2015/07/Malcolm_D_Souza_Intl_Innovation_135_Research_Media.pdf).

In September 2015, in order to advance the national conversation about diversity and inclusion, the oldest and largest higher education diversity magazine Insights into Diversity, published an article highlighting the efforts within our Cannon Scholar program (http://www.insightintodiversity.com/wesley-cannon-scholars-program-provides-support-for-low-income-stem-majors/).

In April 2016, I provided input to a detailed study about greenest US States (https://wallethub.com/edu/greenest-states/11987/#malcolm-j-d-souza).

In May 2016, I authored an article for the Delware News Journal, Projecting the Future: STEM Job Prospects Will Boom (http://wesley.edu/wp-content/uploads/2015/03/Projecting-the-future_-STEM-job-prospects-will-boom.pdf).

In November 2016, I was a panelist on the Delaware STEMCouncil’s STEM Symposium (http://delawarestem.org/news/history-has-‘not-told-complete-story-all-scientists’-leaders-talk-equality-stem).

In 2017, I was involved in an Obesity Case Study with fellow Wesley faculty and students.

To help build a STEM capable workforce with increased participation from women and underrepresented minorities, I established the Wesley College’s STEM program launched the STEM Undergraduate Research – Center for Analytics, Talent and Success (UR-CATS) (http://wesley.edu/news/wesley-stem-launches-innovative-interdisciplinary-program).

Publications (past five years)

2017
“Correlation Analysis of the Rates of Solvolysis of 4-Bromopiperidine: A Reaction following a Grob Fragmentation Pathway,” Kevill, D. N.; Ryu, Z. H.; D’Souza, M. J. European Journal of Chemistry, 2017, Under Review
“Investigation of Obesity-Related Mortality Rates in Delaware,” D’Souza, M. J.; Wentzien, D. E.; Bautista, R. C.; Gross, C. E. American Journal of Health Sciences, 2017, In Press
“Descriptive and Inferential Statistics In Undergraduate Data Science Research Projects,” D’Souza, M. J.; Brandenburg, E. A.; Wentzien, D. E.; Bautista, R. C.; Nwogbaga, A. P.; Miller, R. G.; Olsen, P. E. In, Advances in Statistical Methodologies and Their Applications to Real Problems. ISBN 978-953-51-4962-0. Editor; Tsukasa Hokimoto, Hokkaido Information University, Japan. INTECH-Open Access. 2017. In Press

2016
“Integrative Approach for a Transformative Freshman-Level STEM Curriculum,” D’Souza, M.J.; Curran, K.L.; Olsen, P.E.; Nwogbaga, A.P.; Stotts, S. Journal College Teaching & Learning, 2016, 13 (2), 47-64. PMCID: PMC4824183
“Mechanistic Studies of the Solvolyses of Carbamoyl Chlorides and Related Reactions,” Review Chapter, D’Souza, M.J.; Kevill, D.N. International Journal of Molecular Science, 2016, 17 (111), 20 pages, doi:10.3390/ijms17010111. PMCID: PMC4730352

2015
“Integrative Wesley College Biological Chemistry Program Includes the Use of Informatics Tools, GIS and SAS Software Applications,” D’Souza, M. J.; Kashmar, R. J.; Hurst, K.; Fiedler, F.; Gross, C. E.; Deol, J. K.; Wilson, A. Contemporary Issues in Education Research, 2015, 8 (3), 193-214. PMCID: PMC4505611
“Strategies and Initiatives that Revitalize Wesley College STEM Programs,” D’Souza, M. J.; Kroen, W. K.; Stephens, C. B.; Kashmar, R. J. The Journal of College Teaching and Learning, 2015, 12(3), 195-208. PMCID: PMC4501633
“Evolution of a Structure-Searchable Database into a Prototype for a High-Fidelity SmartPhone App for 62 Common Pesticides Used in Delaware,” D’Souza, M.J.; Barile, B.; Givens, A.F. International Conference on Industrial Instrumentation and Control (2015 ICIC), IEEE XPlore, 2015, 71-76. PMC4604753
“Effect of Gender and Lifestyle Behaviors on BMI Trends in a Sample of the First State’s Undergraduate Population,” D’Souza, M. J.; Walls, K-J. E.; Rojas, C.; Everett, L. M.; Wentzien, D. E. American Journal of Health Sciences, 2015, 6(1), 59-74. PMCID: PMC4459742
“Statistical Methods for the Investigation of Solvolysis Mechanisms Illustrated by the Chlorides of the Carbomethoxy Protecting Groups NVOC and FMOC,” D’Souza, M. J.; Deol, J. K.; Pavey, M. T.; Kevill, D. N. Journal of Analytical Methods in Chemistry, 2015, vol. 2015, Article ID 941638, 8 pages, doi:10.1155/2015/941638, PMID:4342068

2014
Review Chapter. “Influence of Sulfur for Oxygen Substitution in the Solvolytic Reactions of Chloroformate Esters and Related Compounds,” D’Souza, M. J.; Kevill, D. N. International Journal of Molecular Sciences, 2014, 15, 18310-18332, PMID: 25310653
“LFER Studies Evaluating Solvent Effects on an ?-Chloro- and two 1 ?,?,?-Trichloro- Ethyl Chloroformate Esters,” D’Souza, M. J.; Sandosky, B.; Fernandez-Bueno, G. A., McAneny, M. J. Canadian Chemical Transactions, 2014, 2, 160-174, PMID: 24812595

2013
“Manipulating In-House Designed Drug Databases for the Prediction of pH-Dependent Aqueous Drug Solubility,” D’Souza, M. J.; AlAbed, G. J.; Earley, M.; Roberts, N.; Gerges, F. J. American Journal of Health Sciences, 2013, 4, 137-150, PMID: 24478935
Review Chapter. “Application of the Grunwald-Winstein Equations to Studies of Solvolytic Reactions of Chloroformate and Fluoroformate Esters,” D’Souza, M. J.; Kevill, D.N. Research Recent Developments in Organic Chemistry, 2013, 13, 1-38, Editor, S. G.. Pandalai. Publisher, Transworld Research Network, Trivandrum-695 023 Kerala, India, ISBN: 978-81-7895-600-8, PMC4215406
“Kinetic Studies that Evaluate the Solvolytic Mechanisms of Allyl and Vinyl Chloroformate Esters,” D’Souza, M. J.; Givens, A.F.; Lorchak, P.A.; Greenwood, A.E.; Gottschall, S.M.; Carter, S.E.; Kevill, D. N. International Journal of Molecular Sciences, 2013, 14, 7286-7301. PMID: 23549265

2012
“Inter-institutional Partnerships Propel a Successful Collaborative Undergraduate Degree Program in Chemistry,” D’Souza, M. J.; Wang, Q. J. College Teaching and Learning, 2012, 9, 245-252, PMID: 24273464
“Correlation of the Rates of Solvolysis of tert-Butyl Chlorothioformate and Observations Concerning the Reaction Mechanism,” Kyong, J.B.; Lee, Y.; D’Souza, M.J.; Mahon, B.P.; Kevill, D.N. European Journal of Chemistry, 2012, 3, 267-272, PMC3607629
“Evaluation of Electronic Effects in the Solvolyses of p-Methylphenyl and p-Chlorophenyl Chlorothionoformate Esters,” D’Souza, M. J.; Hampton, O. N.; Sansbury, B. M. Journal of Chemistry, Vol. 2013, 2012, Article ID 248534, 9 pages, PMID: 24377055
“Nucleophilic Participation in the Solvolyses of (Arylthio)methyl Chlorides and Derivatives: Application of Simple and Extended Forms of the Grunwald-Winstein Equations,” Kevill, D. N.; Park, Y. H.; Park, B.-C.; D’Souza, M. J. Current Organic Chemistry, 2012, 16, 2012, 1502-1511, PMID: 22711999
“Use of Linear Free Energy Relationships (LFERs) to Elucidate the Mechanisms of Reaction of a ?-Methyl-?-alkynyl and an ortho-Substituted Aryl Chloroformate Ester”, D’Souza, M .J.; Knapp, J. A.; Fernandez-Bueno, G. A.; Kevill, D. N. International Journal of Molecular Sciences, 2012, 13, 665-682, PMC3269712

Degrees

Ph.D., Organic Chemistry, Northern Illinois University
M.S., Organic Chemistry, Northern Illinois University
M.S., Inorganic Chemistry, University of Bombay
B.S., Chemistry, University of Bombay
Courses Taught
BI406 Research Methods
BI407 Experimental and Project Research
CH130 Chemistry for Allied Health
CH200 Organic Chemistry I
CH210 Organic Chemistry II
CH265/365 Directed Research
CH326 Biochemistry

Agenda

(Information subject to change)

Wednesday, August 16th

2:00 - 9:00 PM Registration Desk Hours of Operation (Diamond Foyer)
5:00 - 6:00 PM Reception and Poster Session I Setup (Emerald Promenade)
6:00 - 6:15 PM Welcoming Remarks (Emerald I-III Ballrooms) Ralph Budd, MD, Director, Vermont Center for Immunology and Infectious Diseases, UVM College of Medicine, Judith Van Houten, PhD,  Director, Vermont Genetics Network, UVM President Thomas Sullivan and UVM Provost David Rosowsky, PhD
6:15 - 7:30 PM Plated Dinner (Emerald I-III Ballrooms)
7:30 - 9:00 PM Poster Session I (Undergraduate students and Cores) (Emerald Promenade)

Thursday, August 17th

COBRE/INBRE Business Grant Managers Meeting with Arina Kramer, Grants Specialist at the Center for Research Capacity Building, NIGMS (Carlton Boardroom)
7:00 AM - 5:30 PM Registration Desk Hours of Operation (Diamond Foyer)
7:00 - 8:15 AM Breakfast, Career Tables for interested students, Poster Session II Set-up (Exhibition Hall)
8:30 - 9:15 AM Opening Remarks (Emerald I-III Ballrooms) NIGMS staff:
9:30 - 10:00 AM Break and Refreshments (Emerald Promenade)
10:00 - 12:00 PM Concurrent Sessions
  1. Core Presentations of resources available to NERIC investigators (about 20 min each, followed by table discussions with individual Core leaders) (Emerald III Ballroom)
    • Eric Kmiec, PhD, Helen F. Graham Cancer Center & Research Institute, Newark, DE
      "CRISPR-based Gene Editing in Biomedical Research"
    • Youngwook Ahn, PhD, Brown University Transgenics and Gene-Targeting Facility
      “CRISPR/Cas9 Mouse Preparation”
    • Bongsup Cho, PhD, Coordinator INBRE and Professor, The University of Rhode Island
      "Expanding Bioinformatic Core: 3D printing of molecules and viruses!”
    • Nagib Ahsan, PhD, Brown University
      "Proteomics Core Facility"
    • Calvin Vary, PhD, Maine Medical Research Institute
      "Lipidomics"
    • Dwight Matthews, PhD, University of Vermont
      "Metabolomics and 13C-labeling"
  2. Entrepreneurship Workshop: how to turn your innovative ideas into reality. (Emerald II Ballroom)
    • Keynote speaker, Mathew Portnoy, PhD, Overall HHS SBIR/STTR Program Manager, NIH Program Manager, NIH Office of Extramural Programs
    • Pitch presentations by IDeA entrepreneurs
    • Mercedes Rincón, PhD,  Associate Professor, Medicine Immunobiology Program, UVM College of Medicine
      "Welcome to the I-Trep program for IDeA states"
    • Three Round tables, topics to choose
  3. INBRE Program (Emerald I Ballroom)
    • 10:00 - 11:00 AM - Sharon O'Connor, MS, MBA, Internal Evaluation Manager, Dartmouth College, New Hampshire INBRE
      "INBRE Program Evaluation"
    • 11:00 - 12:00 PM - Elizabeth Ambos, PhD, Executive Officer, Council on Undergraduate Research
      "PM Council on Undergraduate Research Presentation"
10:30 - 11:30 AM COBRE/INBRE Business Grant Managers Meeting with Arina Kramer, Grants Specialist at the Center for Research Capacity Building, NIGMS (Carlton Boardroom)
12:00 - 1:30 PM Lunch and Networking (Exhibition Hall)

VGN Baccalaureate Partner Institution Meeting (Carlton Boardroom)
1:30 - 3:30 PM Concurrent Scientific Sessions (solicit themes from PIs and from abstracts received). Development/Genetics (Emerald I Ballroom) Chair, Cancer (Emerald III Ballroom) Chair,
  • Featured Speaker: Patrycja Dubielecka, PhD, Brown University
    “Beyond JAK/STAT: Signaling Pathways Contributing to the Pathogenesis of Myeloproliferative Neoplasms”
Infectious Diseases and Immunology (Emerald II Ballroom) Chair, William Green, PhD, Professor of Microbiology and Immunology, Geisel School of Medicine, Dartmouth
3:30 - 3:45 PM Break and Refreshments (Emerald Promenade)
3:45 - 4:45 PM Keynote Lecture I (Emerald III Ballroom)
4:45 - 6:00 PM Poster Session II (Graduate students and Postdoctoral Fellows) (Emerald III Ballroom)
6:00 PM Dinner on your own in Burlington

Friday, August 18th

8:00 - 9:00 AM Breakfast (Exhibition Hall)
9:00 - 10:00 AM Cool ideas from IDeA programs (Emerald III Ballroom)
  • Bruce Stanton, PhD, Professor of Microbiology and Immunology, Geisel School of Medicine, Dartmouth
    “Leveraging COBRE Resources with Philanthropy”
  • Marie Stuart, MD, PI of SCD COBRE Program, Director of Hematology Research A.I. DuPont Hospital for Children
    “Single Disease Centered COBREs…A Novel Approach”
  • W. Kelley Thomas, PhD, Professor, Dept. Molecular, Cellular and Biomedical Sciences, University of New Hampshire
    “Early Undergraduate Experiences in Bioinformatics”
10:00 - 12:00 PM Concurrent Scientific Sessions Neuroscience (Emerald I Ballroom) Chair, Judith Van Houten, PhD
  • Featured Speaker: Matthew E. R. Butchbach, PhD, University of Delaware
    "Characterization of Small Molecule Neuroprotectants for Spinal Muscular Atrophy”

Cardiovascular and Pulmonary Systems (Emerald III Ballroom) Chair, Bruce Stanton, PhD

Bioinformatics, Computational Biology, Complex Systems (Emerald II Ballroom) Chair, Cathy Wu, PhD, Edward G. Jefferson Chair of Bioinformatics & Computational Biology, University of Delaware
  • Featured Speaker: Benjamin King, PhD, University of Maine
  • Featured Speakers: Dr. Malcolm D’Souza and Dr. Derald Wentzien from Delaware INBRE Wesley College
    “Undergraduate Data Science Research Projects Form an Integral Component of the Wesley College Science and Mathematics Curriculum”
12:00 - 1:00 PM Lunch and Networking Box lunches (G's Restaurant)
1:00 PM Conference Concludes