NERIC 2017 Speakers

Charles Irvin, PhD

Charles Irvin, PhD

Professor of Medicine, Pulmonary Medicine
Department of Medicine

Education

1968-1972 B.S. Degree (Biology) Carroll College Waukesha, Wisconsin
1972 – 1978 Ph.D. Degree (Physiology) University of Wisconsin Madison, Wisconsin

Academic Appointments

1973 – 1975 Teaching Assistant Department of Physiology University of Wisconsin Madison, Wisconsin
1975 – 1978 Research Assistant Department of Preventive Medicine University of Wisconsin Madison, Wisconsin
1978 – 1980 Post Doctoral Fellow, NIH-NRSA (HL #05784) Meakins-Christie Laboratory McGill University Montréal, Québec, Canada
1981-1988 Assistant Professor of Medicine Pulmonary Sciences Division University of Colorado Health Sciences Center Denver, Colorado
1981 – 1992 Associate Director Pulmonary Physiology Unit National Jewish Center for Immunology and piratory Medicine Denver, Colorado
1988 – 1995 Associate Professor of Medicine Division of Pulmonary Sciences and Critical Care Medicine University of Colorado Health Sciences Center, Denver, Colorado
1992 – 1998 Director Pulmonary Physiology Unit, National Jewish Medical and Research Center Denver, Colorado
1995 -1998 Senior Faculty Member Department of Medicine and Pediatrics National Jewish Medical and Research Center Denver, Colorado
1995 -1998 Professor Department of Medicine Division of Pulmonary Sciences and Critical Care Medicine University of Colorado Health Sciences Center, Denver, Colorado
1999 – 2000 Interim Chief Division of Pulmonary Sciences and Critical Care Medicine
1998 – Present Director Vermont Lung Center Fletcher Allen Healthcare University of Vermont
1998 – Present Professor Department of Medicine Department of Molecular Physiology and Biophysics University of Vermont Burlington, Vermont
2001-present Associate Chair for Research Affairs Department of Medicine

Research Grants

American Lung Association Asthma Clinical Research Center Charles G. Irvin, Principal Investigator (10% effort)2002 – 2004 $1,000,000 (total award)
Merck – Merck & Co. Inc Charles G. Irvin, Principal Investigator 2000 – open $58,174 (total award)

P20 RR15557-01 – National Center for Research Resources (NIH) Center of Biomedical Research Excellence (COBRE)Translational Research in Lung Biology and Disease Charles G. Irvin, Principal Investigator (10% effort)COBRE Administration 9/30/00 – 9/29/05$6,199,452 direct cost. $9,197,900 total cost
P20 RR15557-01 – National Center for Research Resources (NIH) Center of Biomedical Research Excellence (COBRE) Project 4: Elucidation of the role of altered pulmonary proteolysis in the pathogenesis of asthma. Charles G. Irvin, Monitoring Investigator (20% effort)9/30/00 – 9/29/05 $229,091 year 1 direct cost. $1,661,059 total 5 yr. cost

PO1 HL 67004 – National Institutes of Heart, Blood and Lung (NHBLI)Program Project Grant: “Signaling in epithelial injury, proliferation and fibrosis” Principal Investigator: Brooke Mossman, Ph.DProject (2) title: “Signaling in bronchiolar epithelium and airway fibrosis” Prin. Investigator: Charles G. Irvin, Ph.D.(20% effort) 4/01/01 – 3/31/06 $151,161 year 1 direct cost. $793,001 total 5 yr. costs
RO1 HL/EB 67273 – National Heart, Lung and Blood Institute Assessment of Lung Function in Mice PI: Jason H.T. Bates, PhD.,D.Sc Co-Investigator: Charles G. Irvin, Ph.D. (20% effort)12/01/01 – 11/30/04 $225,000 year 1. $1,021,500 total costs

RO1 HL69136-01 – National Institute of Health Lung Epithelium-derived IL-6 in CD4+ T cell immune response PI: Mercedes Rincon, PhD Co-Investigator: Charles G. Irvin, PhD. (10% effort) 10/01/01-09/30/05 $4,000.000 total award
RO1 20815 – National Heart, Lung and Blood Institute Jerome A. Dempsey, Principal Investigator Charles G. Irvin, Research Associate 7/1/77 – 7/10/78 $195,000

F32 05784 – National Heart, Lung and Blood Institute Charles G. Irvin, Postdoctoral Fellow NSRA Fellowship 9/10/78 – 9/9/80 $65,000
R23 28025 – National Heart, Lung and Blood Institute Young Investigator Award Charles G. Irvin, Principal Investigator 3/1/82 – 2/28/85 $107,500

Boehringer – Boehringer Ingelheim Pharmaceuticals Reuben M. Cherniack and Charles G. Irvin, Co-investigators 1/84 – 2/86 $40,000
Purdue Frederick – Purdue Frederick Pharmaceuticals Charles G. Irvin, Principal Investigator 10/90 – 1992 $65,000

ALA-Colorado – American Lung Association of Colorado Charles G. Irvin, Principal Investigator 2/1/86 – 1/31/87 $8,000
PO1 36577 – National Heart, Lung and Blood Institute Gary L. Larsen, Principal Investigator Charles G. Irvin, Principal Investigator, Project 2 7/1/86 – 6/30/96 $150,000/year
Cortech – Evaluation of CP-1027B4 Aerosol in a Rat Bronchospasm Model Charles G. Irvin, Principal Investigator 5/92 – 5/93 $10,000
Fisons – Charles G. Irvin, Principal Investigator 4/91 – 4/93 $55,000

T-Cell Sciences – Effects of a Compliment Receptor Antagonist on an Animal Model of Asthma Charles G. Irvin, Principal Investigator 6/1/96 – 7/1/97 $30,000
National Jewish CIC – Charles G. Irvin, Principal Investigator 1/1/94 – 12/31/95 $52,880.00

1 N01-HR-16048 – National Heart, Lung and Blood Institute Childhood Asthma Management Program (CAMP) Stanley J. Szefler, Principal Investigator Co-Investigator: 10% effort 6/1/91 – 12/1/99 $12,553 (annual direct) $8,210 (annual indirect) (43%)
PO1 36577 – National Heart, Lung and Blood Institute Program Project Grant Inflammation, Airways Reactivity and Asthma Gary L. Larsen, Principal Investigator Charles G. Irvin, Co-Investigator: Project 2 (9.97% effort)Co-investigator: Project 3 (5% effort), 7/1/96 – 6/30/01 $12,013 (annual direct) $7,057 (annual indirect) (43%)

Glaxo-Wellcome – Early Intervention in Childhood Asthma Stanley Szefler, Principal Investigator Co-Investigator (25% effort)$31,383 (annual direct) $20,525 (annual indirect) (53%)
RO1 – National Heart, Lung and Blood Institute Symptom Perception in Pediatric Asthma Marianne Wamboldt, Principal Investigator Co-Investigator (5% effort)$6,277 (annual direct) $2,937 (annual indirect) (53%)

RO1 – National Heart, Lung and Blood Institute Biochemistry and Biology of 5-Lipoxygenase and Leukotrienes Colin Funk, Principal Investigator Co-Investigator (10% effort)7/1/97 – 6/30/01 $42,483 (annual direct) $22,856 (annual indirect) (53%)
RO1 HL60793 (N. Lee) – National Institute of Health Eosinophil effector functions in the lung Charles G. Irvin, Principal Investigator (10% effort) 1998 – 2001$1,317,060 total award

Glaxo-Wellcome -Physiologic Characteristics of the Lung Parenchyma in Near-Fatal Asthma Charles G. Irvin, Principal Investigator (10% effort) 7/1/96 – 6/30/98$52,881.87 (current annual direct)
Patent License (IL-12) $29,500 (current annual direct)$36,500 (Med) (current annual indirect)

RO1 HL56638 – National Heart, Lung and Blood InstituteAirway Fibrosis, Lung Mechanics and Hyperresponsiveness Charles G. Irvin, Principal Investigator (35% effort) 1998 – 2002 $172,967 (current annual direct) $91,673 (current annual indirect) (53%)

Awards and Honors

1978 Post Doctoral Fellowship American Lung Association
1978-1980 NRSA Fellowship National Institutes of Health
1980 NRA Travel Award Budapest, Hungary
1981-1984 Young Investigator Award National Institutes of Health, NHLBI
1983 La Société Canadienne de Récherches Cliniques; Schering Travel Award.

Agenda

Wednesday, August 16th

2:00 - 9:00 PM Registration Desk Hours of Operation
(Diamond Foyer)
5:00 - 6:00 PM Reception and Poster Session I Setup
(Promenade)
6:00 - 6:15 PM Welcoming Remarks
(Emerald I-III Ballrooms)

6:15 - 7:30 PM Plated Dinner
(Emerald I-III Ballrooms)
7:30 - 9:00 PM Poster Session I (Undergraduate students and Cores)
(Promenade)

Thursday, August 17th

7:00 AM - 5:30 PM Registration Desk Hours of Operation
(Diamond Foyer)
7:00 - 8:15 AM Breakfast, Career Tables for interested students (Exhibition Hall), Poster Session II Set-up
(Promenade)

  • Tim Hunter, MS, Biotek and Yolanda Nesbeth PhD, Celdara Medical
    "Biotech Career"
  • Corine Farewell, DVM, MBA UVM Innovations
    "Technology Transfer"
  • Charles Irvin, PhD, UVM College of Medicine, Director, Vermont Lung Center, and Ralph Budd, MD, UVM College of Medicine, Director, Vermont Center for Immunology & Infectious Diseases
    "Academic Career"
  • Yanping Liu, MD, PhD, NIH, NIGMS
    "Scientific Careers in Government"
  • Daniel Kolker, PhD, United States Patent and Trademark Office
    “Patent Assessment”
  • Karen Spach, PhD, Senior Medical Writer, Envision Pharma Group
    "Scientific Careers in Government"
8:30 - 9:45 AM Opening Remarks
(Emerald I-III Ballrooms)

NIGMS staff:

  • Yanping Liu, MD, PhD Program Director, NIGMS
    “Overview of Programs in the Center for Research Capacity Building”
  • Arina Kramer, Grants Specialist at the Center for Research Capacity Building, NIGMS
    “IDeA Post Award Management”
9:45 - 10:00 AM Break and Refreshments
(Promenade)
10:00 - 12:00 PM

Concurrent Sessions

  1. Core Presentations of Resources Available to NERIC Investigators
    (Emerald III Ballroom) Chair, Ralph Budd, MD, University Distinguished Professor of Medicine, The University of Vermont Larner College of Medicine

    • Eric Kmiec, PhD, Helen F. Graham Cancer Center & Research Institute, Newark, DE
      "CRISPR-based Gene Editing in Biomedical Research"
    • Youngwook Ahn, PhD, Brown University Transgenics and Gene-Targeting Facility
      “CRISPR/Cas9 Mouse Preparation”
    • Bongsup Cho, PhD, Coordinator INBRE and Professor, The University of Rhode Island
      "Expanding Bioinformatic Core: 3D Printing of Molecules and Viruses!”
    • Nagib Ahsan, PhD, Brown University
      "Proteomics Core Facility"
    • Calvin Vary, PhD, Maine Medical Research Institute
      "Lipidomics"
    • Dwight Matthews, PhD, University of Vermont
      "Metabolomics and 13C-labeling"
  2. Entrepreneurship Workshop: "How to Turn Your Innovative Ideas Into Reality"
    (Emerald II Ballroom)

    • Mercedes Rincón, PhD,   University of Vermont
      "Welcome to the I-Trep program for IDeA states"
    • Keynote speaker, Mathew Portnoy, PhD, Overall HHS SBIR/STTR Program Manager, NIH Program Manager, NIH Office of Extramural Programs
    • Pitch presentations
      • Voot Yin, PhD, MDI Biological Laboratory
      • Qian Chen, PhD, The Warren Alpert Medical School of Brown University/Rhode Island Hospital
    • Round tables (20 minutes each, choose three)
      • Daniel Kolker, PhD, Supervisory Patent Officer, USPTO, and MaryDilys Anderson, PhD, Esq, Finch & Maloney PLLC)
        “Assessing your Invention and Intellectual Property”
      • Samantha Roach-Gerber, VCET, and Erik Monsen, PhD, University of Vermont
        “How To Pitch-How to Sell Your Idea”
      • Cairn Cross, Fresh Tracks Venture
        “Funding Through VC, Angels”
      • Mathew Portnoy, PhD, NIH SBIR Program, and Yolanda Nesbeth, PhD, Celdara Medical
        “Funding Through SBIR/STTR”
      • Sarah O'Connell Kalil, COO, Boston Microfluidics, and Tanya Kanigan, PhD, COO, Genomic Expression Inc.
        “Setting Up Your Startup”
      • Tina Thornton, PhD, University of Vermont
        “I-Trep Program Opportunities”
  3. INBRE Program (Emerald I Ballroom)
    • 10:00 - 11:00 AM - Sharon O'Connor, MS, MBA, Internal Evaluation Manager, Dartmouth College, New Hampshire INBRE
      "INBRE Program Evaluation"
    • 11:00 - 12:00 PM - Elizabeth Ambos, PhD, Executive Officer, Council on Undergraduate Research
      "PM Council on Undergraduate Research Presentation"
10:30 - 11:30 AM COBRE/INBRE Business Grant Managers Meeting with Arina Kramer, Grants Specialist at the Center for Research Capacity Building, NIGMS (Carlton Boardroom)
12:00 - 1:30 PM U.S. Senator Patrick Leahy (Exhibition Hall)

Lunch and Networking
(Exhibition Hall)
VGN Baccalaureate Partner Institution Meeting
(Carlton Boardroom)
1:30 - 3:30 PM

Concurrent Scientific Sessions
Development/Genetics (Emerald I Ballroom) Chair, Bruce Stanton, PhD, Professor of Microbiology and Immunology, Geisel School of Medicine, Dartmouth

  • Featured Speaker: Vicki Losick, PhD, MDI Biological Laboratory
    “Wound Healing the Fruit Fly Way”
  • Featured Speaker: Jodi Camberg, PhD, University of Rhode Island
    "Remodeling protein architectures leads to big changes in cell physiology"
  • Santina Snow, MDI Biological Laboratory
    “The Role of Specific Tissues in Coordinating Changes in Organismal Growth, Longevity and Resilience to Stress in Response to Reduced mRNA Translation in C. Elegans”
  • Aaron Brown, PhD, Maine Medical Center Research Institute
    “A Novel Human Pluripotent Stem Cell-Derived Model of Beige Adipogenesis for Development of Anti-Obesity Therapies”
  • Larissa Williams, PhD, Bates College
    “The Transcription Factor, Nuclear Factor, Erythroid 2 (Nfe2), is a Regulator of the Oxidative Stress Response During Danio Rerio Development”
  • Michaela Reagan, PhD, Tufts University
    “3D Tissue Engineered Design of Bone Marrow Adipose Tissue to Investigate the Influence of Myeloma on Adipocytes and Adipogenesis

Cancer (Emerald III Ballroom) Chair, Mercedes Rincon, PhD, Professor of Medicine, The University of Vermont Larner College of Medicine

  • Featured Speaker: Patrycja Dubielecka, PhD, Brown University
    “Beyond JAK/STAT: Signaling Pathways Contributing to the Pathogenesis of Myeloproliferative Neoplasms”
  • Sonali Barwe, PhD, Alfred I. DuPont Hospital for Children
    “Disseminated Patient-Derived Xenograft Models for Preclinical Testing of New Drugs for Pediatric Leukemia”
  • Mark Perfetto, University of Delaware
    “ADAM9 Cleaves EphrinB1 to Regulate Canonical Wnt Signaling and Colorectal Cancer Cell Migration”
  • Con Sullivan, PhD, University of Maine
    "A Role for the Tumor Necrosis Factor-Alpha-Induced Protein 8-like 1 Gene in Cancer and Inflammation"
  • Sigrid Langhans, PhD, Nemours/Alfred I DuPont Hospital for Children
    “Beta-Hairpin Peptide Hydrogels as Scaffolds for 3D High-Throughput Screening in Drug Discovery”
  • Andrea Villanti, PhD, MPH, Associate Professor, Vermont Center on Behavior and Health, Department of Psychiatry, University of Vermont
    “Characteristics of Young Adult Cigarette Smokers in the U.S.: Findings from the 1st Wave of the PATH Study, 2013-2014”

Infectious Diseases and Immunology (Emerald II Ballroom) Chair, William Green, PhD, Professor of Microbiology and Immunology, Geisel School of Medicine, Dartmouth

  • Featured Speaker: William Landesman, PhD, Green Mountain College
    “Drivers of Variation in theIxodes Scapularis Microbiome”
  • Jason Shapiro, MD, Alpert Medical School, Brown University
    “Immunoglobulin-A Coated Bacteria Represent a Unique Subset of the Microbiome in Patients with Inflammatory Bowel Disease”
  • Md Mahmudul Hasan, University of Vermont
    “Motility of E. Histolytica Through Host Extracellular Matrix: Involvement of Invadosome-like Actin Structures”
  • Rajiv Jumani, University of Vermont
    “Identification and Pharmacokinetic-Pharmacodynamic Modeling of a Piperazine-Based Drug Lead for Cryptosporidiosis”
  • Hacene Boukari, PhD, Delaware State University
    “Tracking HIV Viruses in Human Cervical Mucus”
  • Victoria DeVault, University of Vermont
    “Natural Genetic Variation within a 0.1Mbp Genetic Interval on Chromosome 1 Regulates NKT Cell Development and Function”
3:30 - 3:45 PM Break and Refreshments
(Promenade)
3:45 - 4:45 PM Keynote Lecture I
(Emerald III Ballroom)

  • Jason McLellan, PhD, Geisel School of Medicine at Dartmouth
    “Developing New Therapeutic Interventions to RSV Infection by Inhibiting the Metamorphosis of the RSV Fusion Glycoprotein”
4:45 - 6:00 PM Poster Session II (Graduate students and Postdoctoral Fellows)
(Promenade)
5:30 - 6:30 PM NIH COBRE and INBRE PI Meeting
(Universal Amphitheater)
6:00 PM Dinner on your own in Burlington

Friday, August 18th

8:00 - 9:00 AM Breakfast
(Exhibition Hall)
9:00 - 10:00 AM

Cool ideas from IDeA programs (Emerald III Ballroom) Chair, Charles Irvin, PhD, Professor of Medicine, The University of Vermont Larner College of Medicine

  • Bruce Stanton, PhD, Professor of Microbiology and Immunology, Geisel School of Medicine, Dartmouth
    “Leveraging COBRE Resources with Philanthropy”
  • Marie Stuart, MD, PI of SCD COBRE Program, Director of Hematology Research A.I. DuPont Hospital for Children
    “Single Disease Centered COBREs…A Novel Approach”
  • W. Kelley Thomas, PhD, Professor, Dept. Molecular, Cellular and Biomedical Sciences, University of New Hampshire
    “Early Undergraduate Experiences in Bioinformatics”
10:00 - 12:00 PM

Concurrent Scientific Sessions

Neuroscience (Emerald I Ballroom) Chair, Melissa A. Harrington, PhD, Associate VP for Research, Delaware State University

  • Matthew E. R. Butchbach, PhD, Nemours/Alfred I. duPont Hospital for Children
    "Characterization of Small Molecule Neuroprotectants for Spinal Muscular Atrophy”
  • Featured Speaker: Andrew Kennedy, PhD, Bates College
    "Targeting the Tet Enzymes to Enhance Cognition"
  • Neal Mecum, University of New England
    “Lacrimal Gland Excision in Male and Female C57BL/6 Mice Causes Pain- and Anxiety-like Behavior”
  • Michael Dash, PhD, Middlebury College
    “Synaptic Depotentiation Reduces Sleep Need”
  • Leslie Johnson, PhD, Johnson State College
    “More than Just ‘Baby Weight’: Perceived Postpartum Weight Bias and Well-Being in First-Time Mothers”


Infectious Diseases and Immunology II (Emerald III Ballroom) Chair, Ralph Budd, MD, University Distinguished Professor, Medicine, University of Vermont Larner College of Medicine

  • Michael Secinaro, University of Vermont
    “Glycolysis Primes Effector T Cells for Death Through the Induction of Caspase-3 Activity”
  • Melissa Maginnis, PhD, University of Maine
    “Characterization of Cellular Factors Required for JC Polyomavirus Invasion of Host Cells”
  • Abbas Raza, University of Vermont
    “Sex-Specific Regulation of CNS Autoimmunity by the Signal Lymphocytic Activation Molecule (Slam) Locus”
  • Danielle Dube, PhD, Bowdoin College
    “Discovery of Genes Required for Glycoprotein Biosynthesis in the Gastric Pathogen Helicobacter Pylori”
  • Scott Rusin, Dartmouth College
    “Identification of Candidate CK2 Substrates in Mitosis by Quantitative Phosphoproteomics”

Bioinformatics, Computational Biology, Complex Systems (Emerald II Ballroom) Chair, Cathy Wu, PhD, Edward G. Jefferson Chair of Bioinformatics & Computational Biology, University of Delaware

  • Featured Speaker: Benjamin King, PhD, University of Maine

    "microRNA co-expression network dynamics of Pseudomonas aeruginosa infection in the zebrafish, Danio rerio"
  • Featured Speakers: Dr. Malcolm D’Souza and Dr. Derald Wentzien from Delaware INBRE Wesley College
    “Undergraduate Data Science Research Projects Form an Integral Component of the Wesley College Science and Mathematics Curriculum”
  • Shawn Polson, PhD, University of Delaware
    “Markers to Metagenomes and Back Again: Bioinformatics advances toward understanding microbial viruses”
  • Edward Lyman, PhD, University of Delaware
    “Computational Approaches to GPCR Drug Discovery: The Membrane as a Therapeutic Target”
  • Cathy Wu, PhD, University of Delaware
    “Big Data to Knowledge: Integrative Literature Mining and Panomics Analysis for Kinase Cancer Drug Analytics”
12:00 - 1:00 PM Lunch and Networking
Box lunches
(G's Restaurant)
1:00 PM Conference Concludes