NERIC 2017 Speakers

Charles Irvin, PhD

Charles Irvin, PhD

Professor of Medicine, Pulmonary Medicine
Department of Medicine

Education

1968-1972 B.S. Degree (Biology) Carroll College Waukesha, Wisconsin
1972 – 1978 Ph.D. Degree (Physiology) University of Wisconsin Madison, Wisconsin

Academic Appointments

1973 – 1975 Teaching Assistant Department of Physiology University of Wisconsin Madison, Wisconsin
1975 – 1978 Research Assistant Department of Preventive Medicine University of Wisconsin Madison, Wisconsin
1978 – 1980 Post Doctoral Fellow, NIH-NRSA (HL #05784) Meakins-Christie Laboratory McGill University Montréal, Québec, Canada
1981-1988 Assistant Professor of Medicine Pulmonary Sciences Division University of Colorado Health Sciences Center Denver, Colorado
1981 – 1992 Associate Director Pulmonary Physiology Unit National Jewish Center for Immunology and piratory Medicine Denver, Colorado
1988 – 1995 Associate Professor of Medicine Division of Pulmonary Sciences and Critical Care Medicine University of Colorado Health Sciences Center, Denver, Colorado
1992 – 1998 Director Pulmonary Physiology Unit, National Jewish Medical and Research Center Denver, Colorado
1995 -1998 Senior Faculty Member Department of Medicine and Pediatrics National Jewish Medical and Research Center Denver, Colorado
1995 -1998 Professor Department of Medicine Division of Pulmonary Sciences and Critical Care Medicine University of Colorado Health Sciences Center, Denver, Colorado
1999 – 2000 Interim Chief Division of Pulmonary Sciences and Critical Care Medicine
1998 – Present Director Vermont Lung Center Fletcher Allen Healthcare University of Vermont
1998 – Present Professor Department of Medicine Department of Molecular Physiology and Biophysics University of Vermont Burlington, Vermont
2001-present Associate Chair for Research Affairs Department of Medicine

Research Grants

American Lung Association Asthma Clinical Research Center Charles G. Irvin, Principal Investigator (10% effort)2002 – 2004 $1,000,000 (total award)
Merck – Merck & Co. Inc Charles G. Irvin, Principal Investigator 2000 – open $58,174 (total award)

P20 RR15557-01 – National Center for Research Resources (NIH) Center of Biomedical Research Excellence (COBRE)Translational Research in Lung Biology and Disease Charles G. Irvin, Principal Investigator (10% effort)COBRE Administration 9/30/00 – 9/29/05$6,199,452 direct cost. $9,197,900 total cost
P20 RR15557-01 – National Center for Research Resources (NIH) Center of Biomedical Research Excellence (COBRE) Project 4: Elucidation of the role of altered pulmonary proteolysis in the pathogenesis of asthma. Charles G. Irvin, Monitoring Investigator (20% effort)9/30/00 – 9/29/05 $229,091 year 1 direct cost. $1,661,059 total 5 yr. cost

PO1 HL 67004 – National Institutes of Heart, Blood and Lung (NHBLI)Program Project Grant: “Signaling in epithelial injury, proliferation and fibrosis” Principal Investigator: Brooke Mossman, Ph.DProject (2) title: “Signaling in bronchiolar epithelium and airway fibrosis” Prin. Investigator: Charles G. Irvin, Ph.D.(20% effort) 4/01/01 – 3/31/06 $151,161 year 1 direct cost. $793,001 total 5 yr. costs
RO1 HL/EB 67273 – National Heart, Lung and Blood Institute Assessment of Lung Function in Mice PI: Jason H.T. Bates, PhD.,D.Sc Co-Investigator: Charles G. Irvin, Ph.D. (20% effort)12/01/01 – 11/30/04 $225,000 year 1. $1,021,500 total costs

RO1 HL69136-01 – National Institute of Health Lung Epithelium-derived IL-6 in CD4+ T cell immune response PI: Mercedes Rincon, PhD Co-Investigator: Charles G. Irvin, PhD. (10% effort) 10/01/01-09/30/05 $4,000.000 total award
RO1 20815 – National Heart, Lung and Blood Institute Jerome A. Dempsey, Principal Investigator Charles G. Irvin, Research Associate 7/1/77 – 7/10/78 $195,000

F32 05784 – National Heart, Lung and Blood Institute Charles G. Irvin, Postdoctoral Fellow NSRA Fellowship 9/10/78 – 9/9/80 $65,000
R23 28025 – National Heart, Lung and Blood Institute Young Investigator Award Charles G. Irvin, Principal Investigator 3/1/82 – 2/28/85 $107,500

Boehringer – Boehringer Ingelheim Pharmaceuticals Reuben M. Cherniack and Charles G. Irvin, Co-investigators 1/84 – 2/86 $40,000
Purdue Frederick – Purdue Frederick Pharmaceuticals Charles G. Irvin, Principal Investigator 10/90 – 1992 $65,000

ALA-Colorado – American Lung Association of Colorado Charles G. Irvin, Principal Investigator 2/1/86 – 1/31/87 $8,000
PO1 36577 – National Heart, Lung and Blood Institute Gary L. Larsen, Principal Investigator Charles G. Irvin, Principal Investigator, Project 2 7/1/86 – 6/30/96 $150,000/year
Cortech – Evaluation of CP-1027B4 Aerosol in a Rat Bronchospasm Model Charles G. Irvin, Principal Investigator 5/92 – 5/93 $10,000
Fisons – Charles G. Irvin, Principal Investigator 4/91 – 4/93 $55,000

T-Cell Sciences – Effects of a Compliment Receptor Antagonist on an Animal Model of Asthma Charles G. Irvin, Principal Investigator 6/1/96 – 7/1/97 $30,000
National Jewish CIC – Charles G. Irvin, Principal Investigator 1/1/94 – 12/31/95 $52,880.00

1 N01-HR-16048 – National Heart, Lung and Blood Institute Childhood Asthma Management Program (CAMP) Stanley J. Szefler, Principal Investigator Co-Investigator: 10% effort 6/1/91 – 12/1/99 $12,553 (annual direct) $8,210 (annual indirect) (43%)
PO1 36577 – National Heart, Lung and Blood Institute Program Project Grant Inflammation, Airways Reactivity and Asthma Gary L. Larsen, Principal Investigator Charles G. Irvin, Co-Investigator: Project 2 (9.97% effort)Co-investigator: Project 3 (5% effort), 7/1/96 – 6/30/01 $12,013 (annual direct) $7,057 (annual indirect) (43%)

Glaxo-Wellcome – Early Intervention in Childhood Asthma Stanley Szefler, Principal Investigator Co-Investigator (25% effort)$31,383 (annual direct) $20,525 (annual indirect) (53%)
RO1 – National Heart, Lung and Blood Institute Symptom Perception in Pediatric Asthma Marianne Wamboldt, Principal Investigator Co-Investigator (5% effort)$6,277 (annual direct) $2,937 (annual indirect) (53%)

RO1 – National Heart, Lung and Blood Institute Biochemistry and Biology of 5-Lipoxygenase and Leukotrienes Colin Funk, Principal Investigator Co-Investigator (10% effort)7/1/97 – 6/30/01 $42,483 (annual direct) $22,856 (annual indirect) (53%)
RO1 HL60793 (N. Lee) – National Institute of Health Eosinophil effector functions in the lung Charles G. Irvin, Principal Investigator (10% effort) 1998 – 2001$1,317,060 total award

Glaxo-Wellcome -Physiologic Characteristics of the Lung Parenchyma in Near-Fatal Asthma Charles G. Irvin, Principal Investigator (10% effort) 7/1/96 – 6/30/98$52,881.87 (current annual direct)
Patent License (IL-12) $29,500 (current annual direct)$36,500 (Med) (current annual indirect)

RO1 HL56638 – National Heart, Lung and Blood InstituteAirway Fibrosis, Lung Mechanics and Hyperresponsiveness Charles G. Irvin, Principal Investigator (35% effort) 1998 – 2002 $172,967 (current annual direct) $91,673 (current annual indirect) (53%)

Awards and Honors

1978 Post Doctoral Fellowship American Lung Association
1978-1980 NRSA Fellowship National Institutes of Health
1980 NRA Travel Award Budapest, Hungary
1981-1984 Young Investigator Award National Institutes of Health, NHLBI
1983 La Société Canadienne de Récherches Cliniques; Schering Travel Award.

Agenda

(Information subject to change)

Wednesday, August 16th

2:00 - 9:00 PM Registration Desk Hours of Operation (Diamond Foyer)
5:00 - 6:00 PM Reception and Poster Session I Setup (Emerald Promenade)
6:00 - 6:15 PM Welcoming Remarks (Emerald I-III Ballrooms) Ralph Budd, MD, Director, Vermont Center for Immunology and Infectious Diseases, UVM College of Medicine, Judith Van Houten, PhD,  Director, Vermont Genetics Network, UVM President Thomas Sullivan and UVM Provost David Rosowsky, PhD
6:15 - 7:30 PM Plated Dinner (Emerald I-III Ballrooms)
7:30 - 9:00 PM Poster Session I (Undergraduate students and Cores) (Emerald Promenade)

Thursday, August 17th

COBRE/INBRE Business Grant Managers Meeting with Arina Kramer, Grants Specialist at the Center for Research Capacity Building, NIGMS (Carlton Boardroom)
7:00 AM - 5:30 PM Registration Desk Hours of Operation (Diamond Foyer)
7:00 - 8:15 AM Breakfast, Career Tables for interested students, Poster Session II Set-up (Exhibition Hall)
8:30 - 9:15 AM Opening Remarks (Emerald I-III Ballrooms) NIGMS staff:
9:30 - 10:00 AM Break and Refreshments (Emerald Promenade)
10:00 - 12:00 PM Concurrent Sessions
  1. Core Presentations of resources available to NERIC investigators (about 20 min each, followed by table discussions with individual Core leaders) (Emerald III Ballroom)
    • Eric Kmiec, PhD, Helen F. Graham Cancer Center & Research Institute, Newark, DE
      "CRISPR-based Gene Editing in Biomedical Research"
    • Youngwook Ahn, PhD, Brown University Transgenics and Gene-Targeting Facility
      “CRISPR/Cas9 Mouse Preparation”
    • Bongsup Cho, PhD, Coordinator INBRE and Professor, The University of Rhode Island
      "Expanding Bioinformatic Core: 3D printing of molecules and viruses!”
    • Nagib Ahsan, PhD, Brown University
      "Proteomics Core Facility"
    • Calvin Vary, PhD, Maine Medical Research Institute
      "Lipidomics"
    • Dwight Matthews, PhD, University of Vermont
      "Metabolomics and 13C-labeling"
  2. Entrepreneurship Workshop: how to turn your innovative ideas into reality. (Emerald II Ballroom)
    • Keynote speaker, Mathew Portnoy, PhD, Overall HHS SBIR/STTR Program Manager, NIH Program Manager, NIH Office of Extramural Programs
    • Pitch presentations by IDeA entrepreneurs
    • Mercedes Rincón, PhD,  Associate Professor, Medicine Immunobiology Program, UVM College of Medicine
      "Welcome to the I-Trep program for IDeA states"
    • Three Round tables, topics to choose
  3. INBRE Program (Emerald I Ballroom)
    • 10:00 - 11:00 AM - Sharon O'Connor, MS, MBA, Internal Evaluation Manager, Dartmouth College, New Hampshire INBRE
      "INBRE Program Evaluation"
    • 11:00 - 12:00 PM - Elizabeth Ambos, PhD, Executive Officer, Council on Undergraduate Research
      "PM Council on Undergraduate Research Presentation"
10:30 - 11:30 AM COBRE/INBRE Business Grant Managers Meeting with Arina Kramer, Grants Specialist at the Center for Research Capacity Building, NIGMS (Carlton Boardroom)
12:00 - 1:30 PM Lunch and Networking (Exhibition Hall)

VGN Baccalaureate Partner Institution Meeting (Carlton Boardroom)
1:30 - 3:30 PM Concurrent Scientific Sessions (solicit themes from PIs and from abstracts received). Development/Genetics (Emerald I Ballroom) Chair, Cancer (Emerald III Ballroom) Chair,
  • Featured Speaker: Patrycja Dubielecka, PhD, Brown University
    “Beyond JAK/STAT: Signaling Pathways Contributing to the Pathogenesis of Myeloproliferative Neoplasms”
Infectious Diseases and Immunology (Emerald II Ballroom) Chair, William Green, PhD, Professor of Microbiology and Immunology, Geisel School of Medicine, Dartmouth
3:30 - 3:45 PM Break and Refreshments (Emerald Promenade)
3:45 - 4:45 PM Keynote Lecture I (Emerald III Ballroom)
4:45 - 6:00 PM Poster Session II (Graduate students and Postdoctoral Fellows) (Emerald III Ballroom)
6:00 PM Dinner on your own in Burlington

Friday, August 18th

8:00 - 9:00 AM Breakfast (Exhibition Hall)
9:00 - 10:00 AM Cool ideas from IDeA programs (Emerald III Ballroom)
  • Bruce Stanton, PhD, Professor of Microbiology and Immunology, Geisel School of Medicine, Dartmouth
    “Leveraging COBRE Resources with Philanthropy”
  • Marie Stuart, MD, PI of SCD COBRE Program, Director of Hematology Research A.I. DuPont Hospital for Children
    “Single Disease Centered COBREs…A Novel Approach”
  • W. Kelley Thomas, PhD, Professor, Dept. Molecular, Cellular and Biomedical Sciences, University of New Hampshire
    “Early Undergraduate Experiences in Bioinformatics”
10:00 - 12:00 PM Concurrent Scientific Sessions Neuroscience (Emerald I Ballroom) Chair, Judith Van Houten, PhD
  • Featured Speaker: Matthew E. R. Butchbach, PhD, University of Delaware
    "Characterization of Small Molecule Neuroprotectants for Spinal Muscular Atrophy”

Cardiovascular and Pulmonary Systems (Emerald III Ballroom) Chair, Bruce Stanton, PhD

Bioinformatics, Computational Biology, Complex Systems (Emerald II Ballroom) Chair, Cathy Wu, PhD, Edward G. Jefferson Chair of Bioinformatics & Computational Biology, University of Delaware
  • Featured Speaker: Benjamin King, PhD, University of Maine
  • Featured Speakers: Dr. Malcolm D’Souza and Dr. Derald Wentzien from Delaware INBRE Wesley College
    “Undergraduate Data Science Research Projects Form an Integral Component of the Wesley College Science and Mathematics Curriculum”
12:00 - 1:00 PM Lunch and Networking Box lunches (G's Restaurant)
1:00 PM Conference Concludes